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Delivery Systems Development for Gene Therapy


Gene therapy is the method of introducing therapeutic genes or drug materials into host cells to elicit a therapeutic benefit. Our goal is to choose the suitable vector to transfer precise amounts of foreign gene products to each target cell, sequentially allowing expression without causing cytotoxicity. An ideal gene delivery vector needs to overcome the extracellular barriers, including particle clearance mechanisms, nucleic acid degradation and specific targeting, and cellular barriers, including cellular uptake, endosomal escape, nuclear entry and nucleic release. Creative Biolabs provides a broad range of gene therapy platforms in compliance with GMP regulations to manufacture gene delivery vectors that are effective, specific, safe and long lasting for worldwide researchers to apply to the treatment of diseases.

Delivery Systems Development for Gene TherapyFig.1 Delivery Systems for Gene Therapy

Viral Vector Design and Construction

With extensive experience in gene therapy development, Creative Biolabs provides one-stop customized services of design, construction and cloning of virus vectors, simultaneously small to large-scale production of viral vectors with robust quality control. We also provide comprehensive consultation services about the design of viral vector tools and give you advice on selecting project-related serotypes.

Provision of vector-backbones for cloning the therapeutic gene

Development of Polyplexes as Gene Delivery System

Polyplexes also can be widely used to deliver transgenes because they have the ability to interact with negatively charged nucleic acids to spontaneously form nanoparticles. We provide the structural design of safe polyplexes, poly (ethylene imine), chitosan, poly (lactic-co-glycolic acid), poly lactic acid, and decationized polyplexes, et al. and modify their size, shape and surface chemistry.

Development of Dendrimers as Gene Delivery System

Dendrimers can bind to genetic material for efficient gene delivery due to their nanometric size, low host immunogenicity, safety and low costs. Here, we provide a fast, efficient and reliable method for functionalizing the surface of the dendrimers for your convenience.

Development of Stem Cells as Gene Delivery System

With the capability to self-renew and differentiate into various cell types, stem cells can be used to deliver artificially produced molecules for therapy application. First, introducing the therapeutic gene into stem cells in vitro by utilizing gene target technology.Then, returning the modified stem cells to the patients safely and efficiently. Creative Biolabs provides cutting-edge stem cell therapy research services covering every stage of specific stem cell type development, including isolation, expansion, characterization, and differentiation.

Development of Dendritic Cells as Gene Delivery System

Dendritic cells can be used for the induction of antigen-specific T cell response to regulate numerous immune processes. Modification of dendritic cells, including the loading of cytokines, chemokines, costimulatory molecules and antigens, can induce potent protective and therapeutic antitumor immunity.

Development of Bacteria as Gene Delivery System

The modified bacteria with the plasmid carrying therapeutic genes are applied to the target tissue and cells, and then useful transgenes can be expressed through the cleavage of the plasmid. Here, we provide a series of attenuated bacterial strains with customizable design for the treatment of various diseases.

Creative Biolabs is a world-renowned trusted biotechnology company with a skilled team of scientists and years of experience. We are robust with material control and supply chain management, as well as advanced technology of gene therapy. Please feel free to contact us and our experienced technicians will give you the most detailed answers to your questions.

Reference

  1. Mali, S. (2013). Delivery systems for gene therapy. Indian journal of human genetics, 19(1), 3.

For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

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