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Gene Therapy Solutions


In pharmacy, medicine, biochemistry, and chemical engineering laboratories worldwide, gene therapy has become the research hotspot. Gene therapy in Creative Biolabs has evolved with the promise of our products and services, which are on the horizon for the research and treatment of diseases.

With our brilliant scientists, in Creative Biolabs, we have successfully introduced a defined gene sequence into specific cells in order to induce it to secrete a protein that has a putative therapeutic function. Our one-stop service including both gene delivery systems and therapeutic strategies design, which includes but not limited to the development of oncolytic virus, antisense oligonucleotide, RNAi, microRNA and, suicide gene therapy service.

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Development of Oncolytic virus

A growing area of gene therapy treatment for cancer is the use of oncolytic vectors for cancer destruction. Our oncolytic viral products are designed to infect cancer cells and induce cell death through the propagation of the virus, expression of cytotoxic proteins and cell lysis, and this therapy has worked remarkably well in Mammalian models. In Creative Biolabs, a number of different viruses have been developed and used for gene therapy purpose, including vaccinia virus, adenovirus virus, herpes simplex virus type I virus, reovirus, Newcastle disease virus, and vesicular stomatitis Indiana virus. Also, we provide customized developing services to fit various projects.

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Development of Antisense Oligonucleotide

Antisense oligonucleotides (ASOs) are short synthetic nucleic acids or nucleic acid analogs, usually between 13 and 25 bases in length. This kind of product is designed to bind to the target RNA, and our oligonucleotide modulates the expression of the encoded protein product in a sequence-specific manner or in the case of noncoding RNAs inhibits their function. According to exquisite design, the antisense oligonucleotides are showing promise as therapeutic agents broadly applicable to the treatment of human diseases. We provide our customer the single-stranded antisense oligonucleotides developing services case by case.

Development of RNAi

The RNA interference (RNAi) is an ancient, highly conserved intracellular process, whereby short (18–25 nt) double-stranded RNAs direct specific cleavage of complementary mRNAs which is an enzymatic process leading to degradation of messenger RNA (mRNA), resulting in silencing of the translated protein. Through reverse genetics approaches, RNAi has been a widely utilized, rapid, and powerful means to study the function of genes. Our small interfering RNA (siRNA) and short hairpin RNA (shRNA) products have been employed both for target validation, and increasingly, as a means to downregulate proteins for therapeutic benefit. The RNAi developing services, in Creative Biolabs, are related to sequence design, chemical modification, innate immune recognition, and delivery.

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Development of microRNA

The microRNAs (or miRNAs) are short noncoding RNAs acting as regulatory molecules in the cellular environment through posttranscriptional silencing of their target mRNAs. The most common methods of microRNA-caused gene downregulation are translational repression and mRNA degradation. The disbalance of microRNAs (miR-122, miR-34, let-7, and miR-15a) can contribute to significant changes in normal cell homeostasis, and consequently developmental problems or disease emergence. In Creative Biolabs, we provide multiple choices for our customers. Apart from the classical methods like miRNA mimics and antisense short oligonucleotides, these methods have proven to be effective in different experimental models. Also, we are developing the new potential methods like miRNA sponges, tough decoy sponges, and target protectors.

Development of Suicide Gene Therapy

Another therapeutic strategy is called suicide gene therapy, in which cell suicide inducing transgenes introduced into cancer cells. In Creative Biolabs, we provide two major suicide gene therapeutic strategies, the cytosine deaminase/5-fluorocytosine, and the herpes simplex virus/ganciclovir. By using multiple delivery routes, our scientist develop viruses, non-viral vectors, liposomes, nanoparticles, and stem cells to deliver the suicide gene. Our suicide gene therapy development service can be applied to different types of cancer, like colon cancer, head and neck cancer, bladder cancer and so on.

References

  1. P, Z. (2013). Suicide Gene Therapy for Cancer; Old Dog New Tricks. Journal of Genetic Syndromes & Gene Therapy, 04(04).
  2. Cross, D. and Burmester, J. (2006). Gene Therapy for Cancer Treatment: Past, Present and Future. Clinical Medicine & Research, 4(3), pp.218-227.
  3. El-Aneed, A. (2004). An overview of current delivery systems in cancer gene therapy. Journal of Controlled Release, 94(1), pp.1-14.

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  • Tel:1-631-381-2994
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