Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMedium-wave-sensitive opsins (OPN1MWs) belong to G-protein coupled receptors family (GPCRs), characterized by seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The opsins are components of visual pigments, which are known as light-absorbing molecules to mediate vision and is covalently linked to cis-retinal. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequently unequal recombination and gene conversion may occur between these sequences. There are two OPN1MWs have been identified, namely OPN1MW and OPN1MW3. OPN1MW is also known as green cone photoreceptor pigment (GCP), and the deficiency of OPN1MW is a cause of partial colorblindness deutan series (CBD), blue cone monochromacy (BCM), cone dystrophy type 5 (COD5), both are X-linked dysfunction syndrome. OPN1MW3 is an important paralog of opsins, but the information about its function is limited.
Here show two members of medium-wave-sensitive opsins, namely OPN1MW and OPN1MW3. They can transmit the signal to the brain through the coupled G protein and phosphorylation cascade, and the process interacts with a series of signal transduction pathways.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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