Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsPhospholipid-transporting ATPase, also known as aminophospholipid-transporting ATPase, is a class of aminophospholipid flippase that transport aminophospholipid from the outer to the inner leaflet of various membranes depending on the energy from ATP hydrolysis. It contributes to maintaining the asymmetric distribution of phospholipids, which is very essential for the many biological processes. Phospholipid translocation plays a key role in the vesicle formation, vesicle trafficking, and lipid-dependent signaling transduction. Moreover, maintenance of the asymmetric distribution of phospholipids in photoreceptor disk membranes and neuronal axon membranes is associated with the normal visual and auditory function. Besides, phospholipid-transporting ATPase is also involved in the regulation of bile acid homeostasis by transporting phospholipids from the inner leaflet of the canalicular membrane to the outer leaflet.
Here shows part of phospholipid-transporting ATPase in humans including ATP8A2, ATP8B1, ATP11A, ATP11B, and ATP10D. ATP8B1 is located in the small intestine, stomach, pancreas, prostate, liver canalicular, and cholangiocyte. The mutations in ATP8B1 can result in the progressive familial intrahepatic cholestasis type 1. ATP8A2 is expressed in the brain, testis, adrenal, and endometrium. The variants in ATP8A2 are associated with the cerebellar atrophy and a syndrome characterized by cerebellar ataxia and cognitive disabilities. ATP11A is widely expressed in lung and gallbladder. ATP11B is broadly expressed in esophagus and bone marrow. ATP10D is widely expressed in placenta and skin. And mutations in ATP11A, ATP11B, and ATP10D are associated with the progression of tumors.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
