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ATP11A Membrane Protein Introduction

Introduction of ATP11A

ATP11A is encoded by ATP11A gene. It belongs to P4-ATPases family, which actively transport or flip phospholipids across cell membranes. It commonly exists in several tissues, such as liver, skeletal muscle, as well as ovary. Meanwhile, some studies conducted on ATP11B suggest that it is related to many diseases, like colorectal cancer and Leukemia. It has been regarded as a biomarker for prognosis of colorectal cancer.

Basic Information of ATP11A
Protein Name Probable phospholipid-transporting ATPase IH
Gene Name ATP11A
Aliases ATPIH, ATPIS, KIAA1021
Organism Homo sapiens (Human)
UniProt ID P98196
Transmembrane Times 10
Length (aa) 1134
Sequence MDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWPTATERVQTKSQCLSVEQSTIFMLSQTSSSLSF

Function of ATP11A Membrane Protein

ATP11B, a member of P-type ATPases family, is phosphorylated in their intermediate state and drive uphill transport of ions across membranes. It plays a critical role in many cellular processes associated with the plasma membrane and intracellular membranes. ATP11A can also act as plasma membrane flippase. As with ATP11C, ATP8A2 and ATP11A localized to the plasma membrane in a CDC50A-dependent manner. Meanwhile, research during the past few decades suggest it is associated with various diseases, which provides possibilities for therapeutic applications.

Phylogenetic analysis and membrane topology of P4-ATPases. Fig.1 Phylogenetic analysis and membrane topology of P4-ATPases. (Andersen, 2016)

Application of ATP11A Membrane Protein in Literature

  1. Tsuchiya M., et al. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 2018, 9(1): 2049. PubMed ID: 29799007

    This article reports that the underlying mechanism and interaction among ATP11A, CDC50A, and PIEZO1. These results suggest that cell surface flip-flop of phosphatidylserine acts as a molecular switch for PIEZO1 activation that governs proper morphogenesis during myotube formation.

  2. Li J., et al. Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics. Oncotarget. 2017, 8(61): 103290-103301. PubMed ID: 29262562

    This article reveals that the expression level and difference of plasma proteins in ATB and latent TB infection children patients. The data show that 49 proteins are differentially expressed between LTBI and ATB.

  3. Segawa K., et al. Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. J Biol Chem. 2016, 291(2): 762-72. PubMed ID: 26567335

    Authors in this group analyze the expression levels of 12 human P4-ATPase, such as ATP8A2, ATP11A, and ATP11C, in an ATP11C-deficient cell line. The results indicate that the major flippases at the plasma membrane are ATP11A and ATP11C. ATP8A2 has a specific role in flipping phospholipids in the brain and testis.

ATP11A Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-ATP11A antibody development services.


As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

Reference

  1. Andersen J P, et al. (2016). P4-ATPases as Phospholipid Flippases-Structure, Function, and Enigmas. Front Physiol. 7: 275.

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