Introduction of ATP11A
ATP11A is encoded by ATP11A gene. It belongs to P4-ATPases family, which actively transport or flip phospholipids across cell membranes. It commonly exists in several tissues, such as liver, skeletal muscle, as well as ovary. Meanwhile, some studies conducted on ATP11B suggest that it is related to many diseases, like colorectal cancer and Leukemia. It has been regarded as a biomarker for prognosis of colorectal cancer.
|Basic Information of ATP11A|
|Protein Name||Probable phospholipid-transporting ATPase IH|
|Aliases||ATPIH, ATPIS, KIAA1021|
|Organism||Homo sapiens (Human)|
Function of ATP11A Membrane Protein
ATP11B, a member of P-type ATPases family, is phosphorylated in their intermediate state and drive uphill transport of ions across membranes. It plays a critical role in many cellular processes associated with the plasma membrane and intracellular membranes. ATP11A can also act as plasma membrane flippase. As with ATP11C, ATP8A2 and ATP11A localized to the plasma membrane in a CDC50A-dependent manner. Meanwhile, research during the past few decades suggest it is associated with various diseases, which provides possibilities for therapeutic applications.
Fig.1 Phylogenetic analysis and membrane topology of P4-ATPases. (Andersen, 2016)
Application of ATP11A Membrane Protein in Literature
This article reports that the underlying mechanism and interaction among ATP11A, CDC50A, and PIEZO1. These results suggest that cell surface flip-flop of phosphatidylserine acts as a molecular switch for PIEZO1 activation that governs proper morphogenesis during myotube formation.
This article reveals that the expression level and difference of plasma proteins in ATB and latent TB infection children patients. The data show that 49 proteins are differentially expressed between LTBI and ATB.
Authors in this group analyze the expression levels of 12 human P4-ATPase, such as ATP8A2, ATP11A, and ATP11C, in an ATP11C-deficient cell line. The results indicate that the major flippases at the plasma membrane are ATP11A and ATP11C. ATP8A2 has a specific role in flipping phospholipids in the brain and testis.
ATP11A Preparation Options
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