Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe solute carrier family 4 (SLC4), also known as the bicarbonate-transporter family, includes the products of 10 human genes (SCL4A1-5; A7-11). Among them, nine SLC4 members encode these proteins that transport HCO3-, or related species such as CO32-, across the plasma membrane. Functionally, eight of these proteins fall into two major groups: three Cl-HCO3 exchangers (AE1-3) and five Na+-coupled HCO3- transporters (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE). NBCe1 and NBCe2 transporters are electrogenic while the others are electroneutral. The functions of the other two SLC4 members, AE4 and SLC4A11, are not conclusively established. The SLC4 members share some similarities in hydropathy analysis, inhibition by stilbene derivatives such as DIDS, and glycosylation, but they also differ in the functional characteristics.
In mammals, the SLC4 family transporters play critical roles in several physiological processes, including the carriage of carbon dioxide from the systemic capillaries to the pulmonary capillaries, the secretion or resorption of acid-base equivalents by numerous epithelia, NaCl reabsorption by certain epithelia, the regulation of cell volume in multiple cell types, and the regulation of intracellular pH. SLC4-sequence variations are associated with pathologies of different systems, such as the circulatory system, central nervous system, digestive system, reproductive system, and the urinary system.
Here, we give an introduction of the following human SLC4 members regarding their structure, functional information, tissue distribution of the proteins, associated diseases, gene localization, etc.
In vitro membrane protein studies are challenging due to the difficulty introduced in preparing stabilized functional hydrophobic proteins incorporated into different membrane-like systems. Aided by our cutting-edge Magic™ membrane protein production platform, Creative Biolabs offers traditional membrane mimics such as detergent micelles or proteoliposomes that are frequently used, as well as alternative strategies and methods such as nanodiscs, lipoparticles, and polymers, to facilitate your membrane protein research. As lipid composition is critical for membrane protein solubilization and stabilization, we also provide our Magic™ lipid screening platform to better preserve the structural and functional integrity.
Meanwhile, if you are interested in developing antibodies against these membrane protein antigens, we introduce our Magic™ membrane protein antibody discovery platform to help promote your studies. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
