Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSphingosine 1-phosphate (S1P), a highly active lipid mediator, regulates diverse cellular responses involved in immunity, heart rate, smooth muscle tone, and endothelial barrier function. This phospholipid is abundant in erythrocytes, brain, spleen, and eyes. Signals initiated by S1P are transduced by five S1P receptors, named S1PR1-5. S1P receptors have seven transmembrane segments and are coupled to G-proteins, which transduce their actions. Expression patterns of the five S1PRs vary in tissues and also during development and aging. For instance, S1PR1-3 subtypes are present ubiquitously whereas S1PR4 is expressed in lymphoid tissue and S1PR5 in the spleen and oligodendrocytes.
The S1P signaling system plays essential roles in vascular development and endothelial integrity, control of cardiac rhythm, and routine oral treatment of multiple sclerosis. They are attractive therapeutic targets for several diseases, such as chronic inflammatory pathologies, autoimmunity, and cancer. As a result, several well-characterized agonists and antagonists of S1PRs have been developed, such as FTY720 (oral therapy for relapsing-remitting multiple sclerosis) and SEW2871 (receptor internalization and recycling). Most of these compounds have been directed toward modulating the activity of S1PR1. Novel agonists and antagonists targeting the other S1P receptors remain to be developed in the future. Here, we give an introduction to each of these five receptors regarding the structure, features, functions, recent advances, etc.
To help understand how S1PRs regulate interactions between biological systems, to aid in characterization of complex physiological networks, and to facilitate therapeutic strategy development, Creative Biolabs thus offers our cutting-edge Magic™ membrane protein production platform to incorporate/stabilize your targets of interest into different membrane mimetics, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. These techniques cover both traditionally used methods and newly emerging approaches. Both detergent-assisted and detergent-free approaches are included, which can be selected based on your specific requirements.
Meanwhile, our Magic™ membrane protein antibody discovery platform can provide antibody development services against your membrane target antigens. We also present DNA immunization service for anti-membrane protein antibody development. If you are interested in any of our services, please contact us today and discuss your requirements.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
