Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (IgG-Fv) is formed by an Immunoglobulin G (IgG) and a fragment variable Fv region, in which the Fc of IgG is engineered by KIH. The Fv region of an anti-Ad fiber knob antibody variable domain is fused to the C terminal of an IgG of anti-EPCAM antibody, or vice versa. The format retains desired characteristics of intact antibodies. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.
Ad fiber knob & EPCAM
FuncS; Promising therapeutic agent
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)
Our services and products are only for lab research, not for any diagnostic or therapeutic use.
Welcome! For price inquiries, we will get back to you as soon as possible.
To order, please email