Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv4-Ig) (FVTIG-004)

Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-Ad fiber knob scFv is fused to the CH1 domain of a heavy chain and another anti-EPCAM scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad fiber knob & EPCAM

Type

Appended IgGs

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Breast cancer; Ovary cancer; Colon cancer; Lung cancer

Targets

Target 1

Ad fiber knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

EPCAM

Gene ID

4072

UniProt ID

P16422

Alternative Names

EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

Related products of "Ad fiber knob & EPCAM"

See other bsAb targets related to "Ad fiber knob"

See other bsAb targets related to "EPCAM"

Customer Reviews and Q&As

There are currently no customer reviews or questions for Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv4-Ig) (FVTIG-004). Click the button below to contact us or submit your feedback about this product.

Recombinant Anti-Ad fiber knob x Anti-EPCAM Bispecific Antibody (scFv4-Ig) (CAT#: FVTIG-004)

Specifications

Targets

Customer Reviews and Q&As