Name: Recombinant Human Anti-CD89 x Human Anti-EGFR Bispecific Antibody (Minibody)
SKU: MiniB-H305
Rating: 5 (1 reviews)

Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD89 scFv fused to N-terminus of Knob-CH3 domain and the anti-EGFR scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget macrophages to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Non-small cell lung cancer (NSCLC); Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CD89 & EGFR

Type

Minibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Non-small cell lung cancer (NSCLC); Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD89

Gene ID

2204

UniProt ID

P24071

Alternative Names

FcαRI; FCAR; Fc fragment of IgA, receptor for; CD89; FcalphaRI; immunoglobulin alpha Fc receptor; Fc alpha receptor

Target 2

EGFR

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD89 x Human Anti-EGFR Bispecific Antibody (Minibody) (CAT#: MiniB-H305)

Specifications

Targets

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