Home > Products > CD89 & EGFR > Recombinant Human Anti-CD89 x Human Anti-EGFR Bispecific Antibody (scFv-Fc)

Recombinant Human Anti-CD89 x Human Anti-EGFR Bispecific Antibody (scFv-Fc)  (BSCFV-H305)

Recombinant Anti-CD89 x Anti-EGFR Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD89 specificity or anti-EGFR specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget macrophages to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Non-small cell lung cancer (NSCLC); Solid tumors therapy.

Specifications
Targets
CD89 & EGFR
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD89
Host Animal 1
Mouse
Target 2
EGFR
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Non-small cell lung cancer (NSCLC); Solid tumors
Targets
Target 1
CD89
Gene ID
UniProt ID
Alternative Names
FcαRI; FCAR; Fc fragment of IgA, receptor for; CD89; FcalphaRI; immunoglobulin alpha Fc receptor; Fc alpha receptor
Target 2
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
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