Home > Products > CEA & DTPA > Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (scFv-Fc-scFv)

Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (scFv-Fc-scFv)  (BSTF-137)

Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-CEA scFv is fused to the N-terminus of Fc via a hinge region while another anti-DTPA scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can be used in pretargeting system of PET, radioimaging or radiotherapy. It can mediate targeting of radioactivity to tumor cells. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer imaging and therapy.

Specifications
Targets
CEA & DTPA
Type
scFv-Fc-scFv
Species Reactivity
Human
Target 1
CEA
Host Animal 1
Mouse
Target 2
DTPA
Host Animal 2
Mouse
Application
FuncS; Pretargeting system for radioimaging and radiotherapy
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
CEA
Gene ID
UniProt ID
Alternative Names
CEACAM5; carcinoembryonic antigen; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Target 2
DTPA
Alternative Names
diethylenetriaminepentaacetic acid; DTPA; pentetic acid
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