Home > Products > PD1 & TIM-3 > Recombinant Human Anti-PD1 x Human Anti-TIM-3 Bispecific Antibody (scFv-CH3)

Recombinant Human Anti-PD1 x Human Anti-TIM-3 Bispecific Antibody (scFv-CH3)  (BSFC-H348)

Recombinant Anti-PD1 x Anti-TIM-3 Bispecific Antibody (scFv-CH3) contains two chains. The anti-PD1 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-TIM-3 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind two receptors simultaneously and target unresponsive immune cells. It is designed for the research of Cancers therapy.

Specifications

Targets
PD1 & TIM-3
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
PD1
Host Animal 1
Mouse
Target 2
TIM-3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Cancers

Targets

Target 1
PD1
Gene ID
UniProt ID
Alternative Names
PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
Target 2
TIM-3
Gene ID
UniProt ID
Alternative Names
TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2; T cell immunoglobulin and mucin domain 3; HAVCR2; hepatitis A virus cellular receptor 2

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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