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CD59 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BABFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD38 Human CD59 Human Inquiry
BABFV-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD19 Human CD59 Human Inquiry
BABFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD38 Mouse CD59 Mouse Inquiry
BABFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD19 Mouse CD59 Mouse Inquiry
FABVC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD38 Human CD59 Human Inquiry
FABVC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD19 Human CD59 Human Inquiry
FABVC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD38 Mouse CD59 Mouse Inquiry
FABVC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD19 Mouse CD59 Mouse Inquiry
SCDBC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD38 Human CD59 Human Inquiry
SCDBC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD19 Human CD59 Human Inquiry
SCDBC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD38 Mouse CD59 Mouse Inquiry
SCDBC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD19 Mouse CD59 Mouse Inquiry
BSDBC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD38 Human CD59 Human Inquiry
BSDBC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD19 Human CD59 Human Inquiry
BSDBC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD38 Mouse CD59 Mouse Inquiry
BSDBC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD19 Mouse CD59 Mouse Inquiry
SCDBF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD38 Human CD59 Human Inquiry
SCDBF-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD19 Human CD59 Human Inquiry
SCDBF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD38 Mouse CD59 Mouse Inquiry
SCDBF-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD19 Mouse CD59 Mouse Inquiry
BSFVF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD38 Human CD59 Human Inquiry
BSFVF-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD19 Human CD59 Human Inquiry
BSFVF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD38 Mouse CD59 Mouse Inquiry
BSFVF-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD19 Mouse CD59 Mouse Inquiry
BSDBF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD38 Human CD59 Human Inquiry
BSDBF-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD19 Human CD59 Human Inquiry
BSDBF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD38 Mouse CD59 Mouse Inquiry
BSDBF-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD19 Mouse CD59 Mouse Inquiry
BSTF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD38 Human CD59 Human Inquiry
BSTF-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD19 Human CD59 Human Inquiry
BSTF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD38 Mouse CD59 Mouse Inquiry
BSTF-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD19 Mouse CD59 Mouse Inquiry
BSCFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Human CD59 Human Inquiry
BSCFV-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD19 Human CD59 Human Inquiry
BSCFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Mouse CD59 Mouse Inquiry
BSCFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD19 Mouse CD59 Mouse Inquiry
MNAB-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Human CD59 Human Inquiry
MNAB-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD19 Human CD59 Human Inquiry
MNAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Mouse CD59 Mouse Inquiry
MNAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD19 Mouse CD59 Mouse Inquiry
BSFC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Human CD59 Human Inquiry
BSFC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD19 Human CD59 Human Inquiry
BSFC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Mouse CD59 Mouse Inquiry
BSFC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD19 Mouse CD59 Mouse Inquiry
BSCC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Human CD59 Human Inquiry
BSCC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD19 Human CD59 Human Inquiry
BSCC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Mouse CD59 Mouse Inquiry
BSCC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD19 Mouse CD59 Mouse Inquiry
BIBD-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 Human CD59 Human Inquiry
BIBD-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD19 Human CD59 Human Inquiry
BIBD-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 Mouse CD59 Mouse Inquiry
BIBD-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD19 Mouse CD59 Mouse Inquiry
FABFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Human CD59 Human Inquiry
FABFV-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 Human CD59 Human Inquiry
FABFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Mouse CD59 Mouse Inquiry
FABFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 Mouse CD59 Mouse Inquiry
MiniB-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 Human CD59 Human Inquiry
MiniB-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD19 Human CD59 Human Inquiry
MiniB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 Mouse CD59 Mouse Inquiry
MiniB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD19 Mouse CD59 Mouse Inquiry
SCTB-H184 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 Human CD59 Human Inquiry
SCTB-H118 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Human CD59 Human Inquiry
SCDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Human CD59 Human Inquiry
SCDB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Human CD59 Human Inquiry
FABIG-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Human CD59 Human Inquiry
FABIG-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Human CD59 Human Inquiry
TRIB-H294 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD38 Human CD59 Human Inquiry
TRIB-H220 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Human CD59 Human Inquiry
BSIG-H292 Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Human CD59 Human Inquiry
BSIG-H218 Human Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Human CD59 Human Inquiry
CROSSAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 Human CD59 Human Inquiry
CROSSAB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD19 Human CD59 Human Inquiry
IGFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Human CD59 Human Inquiry
IGFV-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Human CD59 Human Inquiry
BSDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 Human CD59 Human Inquiry
BSDB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD19 Human CD59 Human Inquiry
BSFAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Human CD59 Human Inquiry
BSFAB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Human CD59 Human Inquiry
BSFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Human CD59 Human Inquiry
BSFV-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Human CD59 Human Inquiry
SCTB-089 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 Mouse CD59 Mouse Inquiry
SCTB-018 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Mouse CD59 Mouse Inquiry
SCDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Mouse CD59 Mouse Inquiry
SCDB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Mouse CD59 Mouse Inquiry
FABIG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Mouse CD59 Mouse Inquiry
FABIG-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Mouse CD59 Mouse Inquiry
TRIB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD38 Mouse CD59 Mouse Inquiry
TRIB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Mouse CD59 Mouse Inquiry
BSIG-119 Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Mouse CD59 Mouse Inquiry
BSIG-043 Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Mouse CD59 Mouse Inquiry
CROSSAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 Mouse CD59 Mouse Inquiry
CROSSAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD19 Mouse CD59 Mouse Inquiry
IGFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Mouse CD59 Mouse Inquiry
IGFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Mouse CD59 Mouse Inquiry
BSDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 Mouse CD59 Mouse Inquiry
BSDB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD19 Mouse CD59 Mouse Inquiry
BSFAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Mouse CD59 Mouse Inquiry
BSFAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Mouse CD59 Mouse Inquiry
BSFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Mouse CD59 Mouse Inquiry
BSFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Mouse CD59 Mouse Inquiry

Background

CD59, alternatively referred to as a membrane inhibitor of reactive lysis (MIRL), is a complement-regulating protein anchored on glycosylphosphatidylinositol. Its function is to impede the formation of membrane attack complexes (MACs) by impeding the attachment of C9 to C5b-C8. CD59 exists on all circulating cells and in virtually all organs, although expression levels differ considerably between cell types. CD59 is a critical component in cellular protection against complement-mediated disruption. Phospholipid anchored to inositol (GPI) is the mechanism by which CD59 binds to host cells. Human cytomegalovirus, vaccinia virus, and HIV are among the viruses that avoid complement lysis by incorporating host cell CD59 into their viral envelope. In addition, CD59 has been investigated as a potential immunotherapeutic target for the treatment of particular ailments, including breast cancer.

Fig.1 Illustration of MAC assembly. (Couves, et al., 2023) Fig.1 Illustration of MAC assembly.1

Reference

  1. Couves, Emma C., et al. "Structural basis for membrane attack complex inhibition by CD59." Nature Communications 14.1 (2023): 890.
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