Name: Recombinant Human Anti-CD3 x Anti-GITR x Anti-EPCAM Trispecific Antibody (Single-chain triplebody)
SKU: KLN-1125-LN55
Rating: 5 (1 reviews)

Recombinant Human Anti-CD3 x Anti-GITR x Anti-EPCAM Trispecific Antibody (Single-chain triplebody) is designed to be expressed as a single chain with three scFv units for CD3, GITR and EPCAM. It contains a His-tag at the C/N terminus for affinity purification. This TsAb has 1+1+1 antigen-binding valency, it provides two signals to activate T cells and recruit them to EPCAM+ tumor cells. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & GITR & EPCAM

Type

Single-chain triplebody; Trispecific antibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

GITR

Gene ID

8784

UniProt ID

Q9Y5U5

Alternative Names

GITR; Glucocorticoid-Induced TNFR-Related protein; TNFRSF18; Tumor Necrosis Factor Receptor Superfamily Member 18; Activation-Inducible TNFR Family Receptor; AITR; CD357 Antigen; CD357; GITR-D; ENERGEN; Glucocorticoid-induced TNFR-related protein; UNQ319/PRO364

Target 3

EPCAM

Gene ID

4072

UniProt ID

P16422

Alternative Names

EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

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Recombinant Human Anti-CD3 x Anti-GITR x Anti-EPCAM Trispecific Antibody (Single-chain triplebody) (CAT#: KLN-1125-LN55)

Specifications

Targets

Customer Reviews and Q&As