Biomarkers and Antibodies Development for Respiratory Infections

With wealthy experience in antibody development for R&D, diagnostic, and therapeutic applications, Creative Biolabs now offers our clients a wide range of in vitro diagnostic (IVD) antibody development services targeting multiple respiratory infectious viruses, bacteria, and other pathogenic microbes.

Respiratory infection is broader concept that includes any pathology affecting airways or any of its structures and organs including the nasal cavities, the pharynx (or throat), the trachea (or windpipe), the larynx, the bronchi and bronchioles, the lung tissues, and the respiratory muscles of the chest cage. As being an outside open system that exposed to the environment, the respiratory tract (nasal cavity, pharynx, larynx, lungs) is subject to frequent contact with a wide diversity of viruses, bacteria or other pathogenic microbes. Owing to the different affecting region and the distinct course of disease, the clinical manifestations vary extensively. Coughing, dyspnea, and chest pain are three main symptoms of lung disease as the consequence of respiratory infectious. The pathologies of affecting human respiratory system have a wide range on its aetiologies which is from environmental, namely bacterial or viral infections and distinct sources and types of pollution or allergens, until genetic causes, together with a more or less complex admixture of both.

Biomarkers and Antibodies Development for Respiratory Infections

Natural Defenses of Respiratory Infections

As the respiratory system is exposed to the outside environment, there is a complicated but comprehensive series of defense against pathogens of the inhaled air in the respiratory tract, which also serves as one of the immune system defense first lines. When the inhaled foreign organisms enter into the respiratory tract they are confronted with a protective arsenal that ranges from physical barriers and antimicrobial compounds until immune receptors resulting the generation of cytokines and chemokines that can mediate some killing processes directly or phagocytosis by recruiting immune cells. The cilia and mucus secreted from the mucous membrane lining the nasal cavity, the cilia and sticky layers of mucus in the trachea, lymphatic vessels in the wall of trachea transport cells of the immune system, and bands of muscle surrounding the cartilage of the trachea comprise the defense elements of the upper respiratory tract. The cilia and mucus layers in bronchial tree also play an essential role in eliminating the invaders. Macrophages located within the alveoli of lungs manage the immune defense by releasing antimicrobial compounds and recruiting immune cells to the sites where pathogens present.

Diagnosis and Treatment for Respiratory Infections

The check methods of respiratory diseases often include physical inspection and palpation for masses, tender areas, and abnormal breathing patterns. The medicals will focus on the breathing of patients in a respiratory exam. They will listen for abnormal sounds in your lungs when you breathe to check for fluid and inflammation in the lungs. Examination of the sputum for bacteria allows the identification of a variety of infectious organisms which contributes to the special treatment. Other tools like computed tomography (CT) and magnetic resonance imaging (MRI) also play a limited role in certain condition diagnoses. As to the treatments, antibiotics could be used to bacterial infections while there are no known treatments for many viruses but medications may be used to manage your symptoms.

Based on our extensive experience and advanced IVD platform, Creative Biolabs is able to provide high-quality IVD antibody discovery and development services against various infectious pathogens. If you are interested in our service, please do not hesitate to contact us for more details.

Our services target different respiratory infectious pathogens, including but not limited to:

For Research Use Only.



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