Introduction of TACR2
TACR2 (Tachykinin Receptor 2), a G protein-coupled receptor, is encoded by TACR2 gene. TACR2 is a receptor for the tachykinin neuropeptide substance K, and it can interact with G proteins that activate a phosphatidylinositol-calcium second messenger system. Meanwhile, it is related to peptide ligand-binding receptors and GPCR signaling. Recent studies indicate that it is associated with many diseases, such as Retinitis Pigmentosa 68 and Asthma. It could be a potential diagnostic marker and therapeutic target in the clinic.
|Basic Information of TACR2|
|Protein Name||Tachykinin receptor 2|
|Aliases||NK2R, NKNAR, TAC2R|
|Organism||Homo sapiens (Human)|
|Sequence||MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI|
Function of TACR2 Membrane Protein
The TACR2 belongs to tachykinins receptor family. Various types of the 5'-end of the sequence of TACR2 gene provide the specific receptor affinities. In fact, TACR2 plays a significant role in gastrointestinal (GI) motility, secretion, and visceral sensitivity. Many diseases also have been proved to be related to the TACR2, including uterine leiomyomata, colorectal cancer, and Alzheimer's disease. The TACR2 receptor antagonists have been applied to clinical therapy.
Fig.1 Structure of Neurokinin A protein.
Application of TACR2 Membrane Protein in Literature
This article reports that the expression levels of tachykinins and tachykinin receptors in uterine leiomyomas and matched myometrium.
This article investigates the effect of Tacr2 disruption in mice, and these results show that Tacr2 negatively regulate the expression of nNOS and VIP both in vivo and in vitro.
Authors analyze the differentially expressed genes (DEGs) and feed conversion efficiency (FCE) in fish using RNA sequencing (RNA-Seq).
This article measures the mRNA and protein expression of TACR1, TACR2, and TACR3, and results show differences in expression between the different receptors within these muscle types, but the rank order of the receptor expression does not differ between the different muscle types.
Authors conducted a study in mice to assess the effects of specific activation of the receptors for SP and NKA in the central control of reproductive function in vivo.
TACR2 Preparation Options
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