Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsTransient receptor potential cation channel subfamily M (TRPM) belongs to the family of transient receptor potential ion channels. This subfamily consists of eight different channels, TRPM1-TRPM8. Structurally, TRPM channels have six transmembrane segments (S1-S6), intracellular N- and C-terminals, and pore region that lies between S5 and S6. TRPM channels are involved in calcium and magnesium homeostasis but the relative permeability and mechanisms of the activation of these two cations vary among the TRPM members. TRPM8 has been described as cold receptors, TRPM4 and TRPM5 as calcium-activated nonselective cation channels, TRPM6 and TRPM7 as magnesium-permeable and magnesium-modulated cation channels, TRPM2 as an ADP-ribose-activated channel of macrophages, and TRPM3 as a hypoosmolarity- and sphingosine-activated channel. TRPM3 regulates heat sensation and inflammatory pain. TRPM4 regulates calcium oscillations after T cell activation and prevents cardiac conduction disorders. TRPM5 modulates insulin secretion and sensory transduction in taste cells, while TRPM7 regulates cell adhesion.
TRPM channels have been discovered to be involved in a variety of human diseases, including respiratory diseases, bladder diseases, diabetes, cancer, kidney disorders, and CNS disorders. Their therapeutic potential is being widely investigated. Here, we give an introduction to the following human TRPM channels, focusing on the structure, activation mechanism, functions, and implication in diseases.
A critical step in any in vitro analysis of membrane proteins is to extract the protein of interest in an active and suitable form for purification and further analysis. However, this process is challenging as our aim is to maximally preserve the activity while putting the protein components into un-natural environments. Although this process is difficult and hard to master, an increasing number of membrane proteins have been successfully isolated and solubilized with active forms, using more refined strategies and tools.
As a leader in membrane protein research filed, Creative Biolabs is proud to introduce our powerful Magic™ membrane protein production platform that enables the preparation of different functional formats of membrane proteins, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers, to help advance your brilliant membrane protein studies.
Meanwhile, benefitting from our unparalleled expertise in antibody discovery and engineering, we can also offer high-quality anti-membrane protein antibody discovery services to our clients. We also present DNA immunization service for anti-membrane protein antibody development. If you are interested in any of our services, please feel free to contact us to discuss your requirements.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
