Close

TRPM6 Membrane Protein Introduction

Introduction of TRPM6

Transient receptor potential cation channel subfamily M member 6 (TRPM6), encoded by the gene TRPM6, is a member of TRP family of cation channels. TRPM6 is an Mg²⁺ -permeable channel, mainly expressed in the apical membrane of distal convoluted tubule and brush-border membrane of absorptive cells in the duodenum. TRPM6 is an extraordinary protein comprising two distinct functional moieties: an ion channel segment and an α-type serine/threonine kinase domain. Generally, TRPM6 cannot efficiently form functional channels by itself and needs to assemble with TRPM7. There are seven variants produced by alternative splicing of TRPM6 gene.

Basic Information of TRPM6
Protein Name Transient receptor potential cation channel subfamily M member 6
Gene Name TRPM6
Aliases HSH, HMGX, HOMG, CHAK2, HOMG1
Organism Homo sapiens (Human)
UniProt ID Q9BX84
Transmembrane Times 6
Length (aa) 2022
Sequence MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCKKLPHSWSNVICAEVLGSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEITNSKREATNVRNDQERQETQSSIVVSGVSPNRQAHSKYGQFLLVPSNLKRVPFSAETVLPLSRPSVPDVLATEQDIQTEVLVHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPLSQAKIMQTGGGYVNWAFSEGDETGVFSIKKKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNSTRSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKEEKLMKICKIKNLSGSSEIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEEEYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTNLNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQL

Function of TRPM6 Membrane Protein

As a transient receptor potential ion channel, TRPM6 plays a crucial role in magnesium homeostasis and is essential for magnesium transport in epithelial cells. In addition, it is required for active magnesium absorption in the kidney and gut. Heterologously expressed TRPM6 can form an Mg²⁺- and Ca²⁺-permeable channel, which is regulated by Mg²⁺ and blocked by ruthenium red. TRPM6 mutations cause hypomagnesemia with secondary hypocalcemia (HSH), an autosomal recessive disorder due to a dysfunction of intestinal magnesium absorption and consequent magnesium deficiency. It has been documented that missense mutations in TRPC6 are responsible for a form of familial focal segmental glomerulosclerosis (FSGS) with several typical manifestation, including proteinuria, hypertension, renal insufficiency, and eventually kidney failure. Therefore, TRPC6 may represent a useful therapeutic target in treating chronic kidney disease.

Schematic representation of TRPM6 structure in the plasma membrane. Fig.1 Schematic representation of TRPM6 structure in the plasma membrane.

Application of TRPM6 Membrane Protein in Literature

  1. Luongo F., et al. TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon. Nutrients. 2018, 10(6). pii: E784. PubMed ID: 29912157

    This article demonstrates that TRPM7 cannot replace TRPM6, and that both TRPM6/7 complexes and TRPM6/7-mediated Mg²⁺ absorption are essential for normal human epithelial colon cells.

  2. Morgan C.P., et al. TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction. Front Cell Neurosci. 2018, 12:41. PubMed ID: 29515374

    This article suggests that TRPM6, TRPV6, and TRPM7 are not possible to be the pore-forming subunit of the transduction channel in hair-cell.

  3. Komiya Y., et al. A Nonredundant Role for the TRPM6 Channel in Neural Tube Closure. Sci Rep. 2017, 7(1):15623. PubMed ID: 29142255

    This article demonstrates that both TRPM6 and TRPM7 channels function cooperatively but they show distinct roles during neural tube closure.

  4. Chubanov V., et al. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife. 2016, 5. pii: e20914. PubMed ID: 27991852

    This article suggests that TRPM6 is essential for the maintenance of organismal magnesium ion balance, as it is crucial for prenatal development and survival to adulthood.

  5. Saraç M., et al. Magnesium-permeable TRPM6 polymorphisms in patients with meningomyelocele. Springerplus. 2016, 5(1):1703. PubMed ID: 27757375

    This article reveals that genetic variations in the magnesium ion-permeable TRPM6 ion channel may be associated with etiopathogenesis of meningomyelocele during embryonic development.

TRPM6 Preparation Options

In order to provide high-quality membrane protein preparation service, we have developed the versatile Magic™ membrane protein production platform. Our experienced scientists will do their best to help you find a perfect match in your required formats. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-TRPM6 antibody development services.


With state-of-the-art equipment and a team of highly skilled and dedicated professionals in membrane protein preparation, Creative Biolabs provides the best-quality products and services in a flexible and cost-effective manner. Our comprehensive membrane protein service covers every step of the production process to serve a variety of research requirements. If you are interested in the service we can provide, please feel free to contact us for more information.

Online Inquiry

Verification code
Click image to refresh the verification code.

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us