3D Ex Vivo Human Cervix Tissue Model Introduction

Creative Biolabs offers the 3D ex vivo human cervix tissue model, which can be used as a powerful research tool for dissecting signaling pathways in cervical biology and is important in studying cervical physiological function, drug action, and pathophysiological changes in response to various pathogenic factors.

Overview of Cervical Tissue

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Fig 1. Cervical epithelia and transformation zone formation. Fig 1. The anatomy of the human cervix.¹

Introduction of the 3D Ex Vivo Human Cervix Tissue Model

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Fig 2. Human ectocervical organoid generation from biopsies. Fig 2. Genetic manipulation of HPV negative ectocervical organoids to integrate HPV16 E6E7 oncogenes.²

Applications of 3D Ex Vivo Human Cervix Tissue Model

For the simulation of benign and malignant neoplastic lesions of cervical cancer involving heterogeneous proliferation and malignant transformation of cervical epithelial cells, squamous cell carcinoma, and adenocarcinoma.
For the study of a variety of other cervical-related conditions, including abnormal embryonic development, inflammation, injury, cervical infertility, assisted reproductive technology, cervical and sexual, and cervical pregnancy.
For the study of factors that increase the risk of developing cervical cancer, such as the long-term negative effects of co-infection with pathogens leading to cytoskeletal and Golgi reorganization, disruption of cell junctions, and migration of immune cells in the microenvironment.
Used as a preclinical platform for drug sensitivity testing to determine the discrepancy between results and clinical response and the cause.
Explore therapeutic strategies for cervical disease such as model transplantation and combined estrogen and progestin interventions.

Fig 3. Organoids enable FRT studies, drug testing, and co-culture models. Fig 3. Applications of tissue-derived organoids of the female reproductive tract and placenta.¹

More Genitourinary Tissue Models

Creative Biolabs supports the 3D ex vivo human cervix tissue model as a promising biomedical engineering technology and can address key questions in the study of cervical biologies, pathologies such as infection and cervical cancer, and response to drug-resistant pathogens by quantifying its transcriptome and visualizing its histomorphology features. Please contact us to help with your cervical research project.

References

Alzamil, L.; et al. Organoid systems to study the human female reproductive tract and pregnancy. Cell Death Differ. 2020, 28(1): 35-51. Distributed under Open Access License CC BY 4.0, without modification.
Koster, S.; et al. Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming. Nat Commun. 2022, 13(1): 1030. Distributed under Open Access License CC BY 4.0. The original image was modified by keeping part (a).

Research Model

3D Biology Based Biomarker Discovery