3D Ex Vivo Human Uterine Contractility Model Introduction

The morphological depiction and function of the uterus' interior parts are studied using the uterine contractility model. Creative Biolabs offers 3D ex vivo human uterine contractility model and related services for the research of physiological state of the uterine contraction and fetal delivery.

Introduction of 3D Ex Vivo Human Uterine Contractility Model

Uterus remodeling in preparation for delivery

Increased intercellular coupling and excitability of the smooth muscle layer of the uterus

Uterine contractility throughout labor

1. Rhythmic 2. Symmetry 3. Polarity 4. Retraction effect

3D Ex Vivo Human Uterine Contractility Model

Features

Simulation of influencing factors such as in vivo own muscle strength and tissue toughness.
Contains relevant regulatory cytokines and action receptors.
Preservation of the characteristics of the rhythm and intensity, duration and interval of uterine contractions.
Suitable for describing uterine contractions with respect to amplitude, frequency, and activity of contractions.

Fig 1. Myofibre model overview and validation. Fig 1. A graphic representation of myofiber model.¹

Applications

Research physiological states and influencing factors

Fiber extension degree
Muscle fiber degeneration
Uterine development status
Oxytocin and receptors, estrogen, progesterone and prostaglandins
Uterine fibroids
External causes such as water and electrolyte disorders
Drug effects, including sedatives, analgesics and anesthetics

Research related pathological diseases and drug efficacy testing

Premature birth
Infertility
Irregular menstruation

Advantages of 3D Ex Vivo Human Uterine Contractility Model

The higher degree of simulation
Realistic reproduction of uterine shape and tissue structure.
The higher flexibility and adjustability
Suitable for different operations to observe the anatomy of the uterus
The better reusability
Reusable for multiple experiments
The more convenient operation mode
Provide visualization of uterine vascular and nerve structures for manipulation and observation mode

Advantages of Our Services

The unique 3D bio-support provides the necessary structural support to the model.
Rich and suitable culture substrates support the nutritional requirements for model construction.
Provide models that match reality and reflect health and pathophysiology.
Flexible enough to adapt genes and niche components.

More 3D Ex Vivo Human Genitourinary Tissue Models at Creative Biolabs

Creative Biolabs offers a reliable 3D ex vivo human uterine contractility model to support the study of its associated physiological states and the causes and mechanisms of abnormal states such as contractile weakness. Please feel free to contact us and you will receive a quick response and a solution that meets your specific goals.

Reference

Goldsztejn, U.; et al. A myofibre model for the study of uterine excitation-contraction dynamics. Sci Rep. 2020, 10(1): 16221. Distributed under Open Access License CC BY 4.0. The original image was modified by keeping part (a) only.

Research Model

3D Biology Based Biomarker Discovery