3D Ex Vivo Human Breast Tissue Model Introduction

Creative Biolabs provides the best 3D ex vivo human breast tissue model and its related services to help clients in the field of breast cancer mechanisms and drug evaluation and personalized protocol treatment.

Construction and Features

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Advantages

Cancer cell line model

Low generation efficiency, requiring extensive selection and adaptation to 2D in vitro culture conditions.
Only rare clones are able to expand and sustain multiple passages and lack a hierarchy of multiple cell types.
Derived cell lines may undergo substantial genetic changes and lose the genetic heterogeneity of the original tumor.

Tumor xenograft model

Limited transplantation efficiency for tumor subgroups.
Huge costs for time and materials, etc.
May undergo specific tumor evolution.

Traditional Model

3D Ex Vivo Human Breast Tissue Model

More stable maintenance of high contact polarity between cancer cells and microenvironmental matrices.
More reliable simulation of human breast tissue physiological environment and 3D complex system.
Can perform genetic manipulation of tumor cell lines.
More applicable in the fields of bioprecision medicine, hard-to-treat disease modeling, and new drug screening.
It can reduce the damage and loss of animals in animal experiments and is more economical.

Fig 1. Overview of the human breast organoid derivation process from normal or tumor tissue resections. Fig 1. The general process of human breast organoid derivation.¹

Applications

Elucidating the precise effects of various factors on breast cell transformation and breast cancer development.
Identification of the mechanisms of physiological and pathological changes in breast function and epigenetic patterns of change.
Establishing a platform for long-term drug resistance, toxicity, and safety assessment of drugs.
Genome sequencing and bioinformatics big data crossover applications to develop emerging medical models.

More 3D Ex Vivo Human Genitourinary Tissue Models

Creative Biolabs has a proven 3D ex vivo human breast tissue model platform and is continuously working to provide more accurate research models. Please contact us to facilitate its translational application.

Reference

Mohan, S.; et al. Current status of breast organoid models. Front Bioeng Biotechnol. 2021, 9: 745943. Distributed under Open Access License CC BY 4.0, without modification.

Research Model

3D Biology Based Biomarker Discovery