Native™ Camel Anti-Membrane Protein Antibody Discovery

Native™ Camel Anti-Membrane Protein Antibody Discovery As a trustworthy scientific partner and service provider, Creative Biolabs has long been a dedicated innovator in the areas of antibody discovery and development. Currently, we are confident to present worldwide customers our best-in-field custom service of tailoring native camel anti-membrane protein antibodies based on our exclusive Native™ antibody platform.

As a unique mammal species, camels brings a brand-new idea into antibody development. It has a novel antibody isotype termed as heavy-chain only antibody, which is merely composed of two identical heavy chains without light chains. The heavy-chain only antibodies contain a single monomeric variable region in Fab domains (aka VHH fragments) and count for about 50% of the antibodies in camelids. VHH fragments can be further developed into single domain antibodies (sdAbs), which represent the smallest antibody format with diagnostic and therapeutic activities.

VHH antibodies have many appealing features. The CDR3 loop of VHH domain is much longer than that of conventional antibodies and sometimes stabilized by a disulfide bond, which contributes to binding in cavities, such as enzyme and receptor clefts. Moreover, thanks to their small size, sdAbs are more robust, flexible but with similar specificity and affinity as conventional antibodies. It’s also much easier to transform sdAbs into economical bacterial cells easier, which is more ideal for large-scale production.

Anti-membrane protein antibodies are more and more appealing in clinical trials and therapeutic research. At present, Creative Biolabs offers sdAb discovery service (in camel/llama/alpaca, etc.) using advanced Native™ Antibody Discovery Platform to generate highly specific, highly affinitive antibodies against a variety of membrane antigens.

Typical antibodies (top) and camelid antibodies (bottom). Fig 1 Typical antibodies (top) and camelid antibodies (bottom).

Advantages of Native™ Anti-Membrane Protein sdAb Discovery

As a pioneer and industry leader in the field of antibody generation, Creative Biolabs has more than ten years’ research and development experience. To fulfill customers' demands, we have developed more than ten host species on our platform. If none of them meets your requirement, our experienced scientists will be glad to work out a customized solution for you. Please feel free to contact us for more details.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

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