Native™ Human Anti-Membrane Protein Antibody Discovery

With seasoned expert team and vast experience, Creative Biolabs now provides integrated service of fully human anti-membrane protein antibody discovery based on our exclusive Native™ platform.

Native™ Human Anti-Membrane Protein Antibody Discovery Membrane proteins, such as GPCRs and ion channels, participate in many key physiological activities. Monoclonal anti-membrane protein antibodies for treatment of autoimmune diseases, transplantation side effects and cancers in clinic now exert tremendous medical impacts in recent years. Till now, more than 50 monoclonal antibodies have been approved in market, with numerous candidates under development stage. However, to obtain superior antibodies against membrane proteins is very challenging. Some conventional approaches (e.g. hybridomas, phage display) may be restricted in many aspects, for instance, small candidate pool, low efficiency, species limitation, loss of native VH-VL pairs, etc. After years of efforts and exploration, Creative Biolabs has successfully established a cutting-edge Native™ Antibody Discovery Platform as a promising solution.

As is known, B cells are responsible for antibody secretion in humoral immune responses. However, there are only a small fraction of them (usually less than 1%) that are capable of specific antigen recognition. Based on innovative antigen-specific B cell cytometry, we can isolate the particular population of antigen-specific B cells, creating a high-quality candidate pool for raising clones with highest binding affinity and native format at one time.

Advantages of Native™ Human Anti-Membrane Protein Antibody Discovery

Versatile, high-throughput B cell sorting approaches
Native-paired heavy chain and light chain
Minimum immunogenicity concerns (human patient samples)
In vivo affinity maturation
Good developability (solubility, stability, etc.) in vivo
Large pool of antibody candidates that can generate hundreds of candidates at one time

Creative Biolabs has been a long-time pioneer in tailoring high-specificity, high-affinity antibodies targeting various membrane proteins. We provide one-stop services from membrane protein immunogen preparation to downstream antibody production and development. Regarding our Native™ platform, we provide a variety of host species to fulfill customers' demands:

Species	Species Antibody Pages
Human	Native™ Human Anti-Membrane Protein Antibody Discovery
Mouse	Native™ Mouse Anti-Membrane Protein Antibody Discovery
Rat	Native™ Rat Anti-Membrane Protein Antibody Discovery
Sheep	Native™ Sheep Anti-Membrane Protein Antibody Discovery
Canine	Native™ Dog Anti-Membrane Protein Antibody Discovery
Goat	Native™ Goat Anti-Membrane Protein Antibody Discovery
Horse	Native™ Horse Anti-Membrane Protein Antibody Discovery
Hamster	Native™ Hamster Anti-Membrane Protein Antibody Discovery
Monkey	Native™ Monkey (NHP) Anti-Membrane Protein Antibody Discovery
Rabbit	Native™ Rabbit Anti-Membrane Protein Antibody Discovery
Chicken	Native™ Chicken Anti-Membrane Protein Antibody Discovery
Camel	Native™ Camel Anti-Membrane Protein Antibody Discovery

Please feel free to contact us for more details, and we will be here for you 24/7.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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