Home > Products > BCMA & TACI > Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Diabody-CH3)

Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Diabody-CH3)  (BSDBC-021)

Recombinant Anti-BCMA x Anti-TACI Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-BCMA and anti-TACI antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind two receptors simultaneously. It is designed for the research of Lymphoma therapy.

Specifications

Targets
BCMA & TACI
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
BCMA
Host Animal 1
Mouse
Target 2
TACI
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Lymphoma

Targets

Target 1
BCMA
Gene ID
UniProt ID
Alternative Names
TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF13A; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
Target 2
TACI
Gene ID
UniProt ID
Alternative Names
TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; CVID; RYZN; TACI; CD267; CVID2; IGAD2; TNFRSF14B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor 13B; transmembrane activator and CAML interactor

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