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Recombinant Human Anti-CD3 x Human Anti-CD4 Bispecific Antibody (scFv-IgG)  (BSSG-H243)

Recombinant Anti-CD3 x Anti-CD4 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CD3 antibody variable domain are respectively connected to the N terminus of the anti-CD4 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget T cells to HIV-1 infected cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Specifications
Targets
CD3 & CD4
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Human
Target 2
CD4
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD4
Gene ID
UniProt ID
Alternative Names
CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3
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