Home > Products > CD3 & CD44 > Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Fab-IgG)

Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Fab-IgG)  (FABIG-068)

Recombinant Anti-CD3 x Anti-CD44 Bispecific Antibody (Fab-IgG) is designed to be expressed as three chains, assembling in vivo and resulting in the construct of Fab-IgG (Tandem Fab-Fc). Fab-IgG has standard Fab and Fc domains, with no mutations, which may permit it has similar affinity binding and PK profile comparable to the parental antibodies. This BsAb can retarget T cells to tumor cells. It is designed for the research of Glioblastoma; Squamous cancer therapy.

Specifications
Targets
CD3 & CD44
Type
Fab-IgG
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
CD44
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Glioblastoma; Squamous cancer
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD44
Gene ID
UniProt ID
Alternative Names
CD44; CD44 antigen; ECMRIII; Extracellular matrix receptor III; HCAM; Homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; HUTCH-1; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109

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