Recombinant Anti-CD64 x Anti-malaria antigen Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-CD64 antibody are fused to the C terminus of an anti-malaria antigen IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can retarget NK cells to genus plasmodium. It is designed for the research of Malaria therapy.