Recombinant Anti-CTLA4 x Anti-GLUT2 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CTLA4 antibody variable domain are respectively connected to the N terminus of the anti-GLUT2 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can bind two factors simultaneously. It is designed for the research of Renal cell cancer (RCC) therapy.
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