Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-DR5 specificity or anti-FAP specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can induce targeted apoptosis by activation of the death receptor. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.
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