Home > Products > DR5 & FAP > Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Tandem scFv-Fc)

Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Tandem scFv-Fc)  (BSFVF-H320)

Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-DR5/FAP tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can induce targeted apoptosis by activation of the death receptor. It is designed for the research of Breast cancer; Ovary cancer; Colon cancer; Lung cancer therapy.

Specifications
Targets
DR5 & FAP
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
DR5
Host Animal 1
Human
Target 2
FAP
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Ovary cancer; Colon cancer; Lung cancer
Targets
Target 1
DR5
Gene ID
UniProt ID
Alternative Names
DR5; Death Receptor 5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; TNFRSF10B
Target 2
FAP
Gene ID
UniProt ID
Alternative Names
FAP; fibroblast activation protein, alpha; FAPA; SIMP; Fibroblast activation protein; DPPIV; prolyl endopeptidase FAP; seprase; FAPalpha; dipeptidyl peptidase FAP; surface-expressed protease; post-proline cleaving enzyme; gelatine degradation protease FAP; F19 cell surface antigen; integral membrane serine protease; serine integral membrane protease; 170 kDa melanoma membrane-bound gelatinase
Our services and products are only for lab research, not for any diagnostic or therapeutic use.

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