Anti-A2M Aptamer SELEX Service(Cat#: CTApt-881)

This is an aptamer development services to screening aptamers binds to the A2M with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target A2M
Alternative Names Alpha-2-Macroglobulin; CPAMD5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 5; Alpha-2-M; FWP007; S863-7; A2MD; A2M
Gene ID 2
UniProt ID P01023
Target Overview The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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