Products

Creative Biolabs understands that advancing complement system research requires not only groundbreaking ideas but also access to the most reliable, high-quality tools and reagents. Our extensive product suite spans antibodies, proteins, assay kits, peptides, inhibitors, sera and plasmas, vectors, lysates, reagents, and aptamers. Each product category has been developed, validated, and optimized by our experienced scientific teams to ensure reproducibility, consistency, and maximum performance in a wide variety of applications.

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Why Complement Related Products Matter

To accelerate the complement therapeutics, researchers need access to robust and reproducible products that can:

Enable precise quantification of complement activation and regulation.
Facilitate functional assays across diverse complement pathways (classical, alternative, lectin).
Support therapeutic development, including antibody drugs, complement inhibitors, and novel biologics.
Provide validated reference materials for benchmarking and cross-study comparison.

Fig. 1 Schematic representation of the complement activation pathways.^1,2

Explore Precision Tools

Our Product Portfolio

Below is an overview of the comprehensive categories we provide to empower complement research. Each section corresponds to a dedicated product family, accessible via specialized subpages on our website.

Antibodies

Antibodies are the cornerstone of complement biology, enabling researchers to interrogate specific complement proteins, fragments, and complexes with unmatched precision. Our antibody collection includes monoclonal and polyclonal, neoepitope-specific, inhibitory and detection antibodies.

Proteins

We provide recombinant and purified complement proteins that maintain native structure and activity. Highlights include classical pathway proteins (C1q, C1r, C1s, C4, C2), alternative pathway proteins (Factor B, Factor D, Properdin), lectin pathway proteins (MBL, MASPs, Ficolins) and terminal pathway proteins (C5-C9).

Assay Kits

Assay kits provide ready-to-use solutions for studying complement activity and inhibition. Our kits cover ELISA kits for C3a, C5a, sC5b-9 quantification, functional hemolysis assays for classical, alternative, and lectin pathway activity, complement inhibition assays for drug screening, and multiplex kits for profiling multiple complement factors simultaneously.

Sera and Plasmas

We provide high-quality sera and plasmas that retain intact complement activity. Options include normal human serum, complement-preserved animal sera, heat-inactivated controls, and pathology-specific sera. They can be applied to complement hemolysis assays, in vitro complement activation studies and more.

Inhibitors

Our inhibitor panel enables precise modulation of complement activity. Categories include small molecule inhibitors of Factor D, C1s, and C3 convertases, peptide inhibitors targeting C3/C5 cleavage, and novel complement regulators engineered for enhanced stability.

Vectors

Complement vectors enable genetic manipulation and expression studies. Products include expression vectors for complement proteins and regulators, CRISPR/Cas9-based vectors for complement gene editing, and reporter vectors for complement pathway activation readouts.

Lysates

Complement lysates provide a rich source of complement proteins for research use. Available formats include cell lysates expressing recombinant complement proteins, tissue lysates for complement profiling, and pathway-specific lysates (e.g., complement regulator-deficient cells).

Reagents

Our complement reagents portfolio includes buffers and substrates optimized for complement assays and reference standards for assay calibration. They can be applied to enhance assay reproducibility, standardize complement research across labs, and provide controls for drug screening assays.

Peptides

Complement peptides are powerful tools for mechanistic exploration. They can be applied to study complement-receptor interactions (C3aR, C5aR1, C5aR2), screen novel drug candidates, and map complement cleavage sites.

Aptamers

Aptamers are emerging as novel molecular tools and therapeutics. We provide DNA and RNA aptamers targeting C3, C5, Factor B, and regulators, high-affinity binders for complement detection, and inhibitory aptamers for complement pathway blockade.

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Workflow Support

Our products integrate seamlessly into customer workflows.

Sample Preparation and Acquisition

Sera, Plasmas, Lysates

Assay Setup and Execution

Kits, Reagents, Controls

Pathway Analysis

Antibodies, Proteins, Peptides, Kits

Therapeutic Evaluation

Inhibitors, Aptamers, Vectors

Data Output & Documentation

Every product is supplied with a comprehensive data package, enabling our clients to integrate materials confidently into their experimental pipelines.

Certificate of Analysis

Identity
Purity
Concentration
Activity

Functional Validation Data

ELISA curves
Hemolysis inhibition profiles
Binding kinetics measured by SPR/BLI

QC Reports

SDS-PAGE analysis
Endotoxin testing
Sterility checks
Batch-to-batch consistency metrics

Guidelines and Notes

Stability and storage guidelines
Optimized protocols
Performance tips

By providing rigorous, transparent, and easy-to-interpret data outputs, Creative Biolabs empowers clients to accelerate their complement research with clarity and precision.

Accelerate Your Research

Customization Options

Many clients require custom-tailored solutions to address specialized experimental designs. That's where our customization capabilities make the difference.

Deliverables.(Creative Biolabs Authorized)

Antibody customization
Protein engineering
Assay kit adaptation
Specialized sera & plasmas
Vector design services
Bulk manufacturing
Long-term supply contracts

Discuss Your Needs

Case Studies

Case 1

CH50 inhibitor assay by using NHS and CH50 Functional Test Kit (CTK-907)

The CH50 is usually used to represent the total complement activity, or screen the activation/deficiency of the classical complement pathway. The degree of hemolysis is related to the content and function of complement components in serum. As the complement content is positively correlated with the degree of hemolysis, not linearly, but in S-curve, the middle part of the reaction curve, i.e. 50% hemolysis (CH50), is usually taken as the end point. If a complement component is deficient or not activated, the membrane attack complex will not be formed, and no hemolysis can be observed.

CH50 functional test.(Creative Biolabs Original)

Fig. 2 Hemolysis inhibitor assay by CH50 functional test kit.

Case 2

AP50 functional test (CTK-908)

The AH50, similar to CH50, is used to represent the total complement activity, or screen the activation/deficiency of the alternative complement pathway. It is available for the sample of plasma or serum of several species, such as human, mouse, rat, guinea pig, bovine, hamster, swine, sheep, monkey. AH50 will be decreased due to hereditary or acquired deficiencies of the alternative pathway. The combination of CH50 and AH50 tests can be used for the identification of the specific pathway abnormality.

AP50 functional test.(Creative Biolabs Original)

Fig. 3 Hemolysis inhibitor assay by AP50 functional test.

References

Frazer-Abel, Ashley, Michael Kirschfink, and Zoltán Prohászka. "Expanding horizons in complement analysis and quality control." Frontiers in immunology 12 (2021): 697313. https://doi.org/10.3389/fimmu.2021.697313
Distributed under Open Access license CC BY 4.0, without modification.

What Our Clients Say

"We purchased multiple assay kits to track C3a and C5a levels in samples. The clarity of the protocols and the robustness of the data allowed our students to run experiments independently with confidence."

— Principal Investigator, Academic Medical Center

"We needed bulk lots of complement sera for large-scale screening. The service was efficient, cost-effective, and ensured an uninterrupted supply for our ongoing program. Their logistics team handled cold chain delivery flawlessly."

—Senior Project Manager, Pharmaceutical Firm

"We collaborated with Creative Biolabs on custom vector design for complement gene modulation. Their scientists worked closely with our team, and the final constructs performed beyond expectations in our disease models."

— CEO, Early-Stage Biotech Startup

"We have been working with Creative Biolabs for over 8 years. Their antibodies, proteins, and aptamers are staples in our lab. What sets them apart is not just product quality, but the responsiveness of their technical support team."

— Laboratory Director, Research Institute

"As an immunology researcher, reliable complement antibodies are critical to our work. Creative Biolabs' reagents have been consistently reproducible across experiments, which directly improved the credibility of our publications."

— Associate Professor, University

Frequently Asked Questions

Can I request custom complement antibodies or proteins?

Yes. We offer customization services, including tailored antibody development, recombinant protein engineering, and assay design to meet specific research needs.

Can your assay kits be adapted for high-throughput screening?

Absolutely. Many of our kits are optimized for high-throughput workflows, enabling efficient screening of complement-targeted inhibitors or modulators.

How quickly can products be delivered?

Stock products are shipped within days, while custom-made reagents may require several weeks depending on complexity. We offer expedited options for urgent research needs.

Can you help integrate your products into our drug discovery pipeline?

Absolutely. Our scientific team provides consultation on product selection, assay design, and integration into discovery workflows, from target validation to preclinical evaluation.

Are your complement assay kits compatible with both human and animal samples?

Yes. Many of our kits are validated for human, mouse, rat, and primate samples. Cross-reactivity data are provided, and we can also customize kits for other species.

Do you support co-development or collaboration projects?

Yes. Beyond supplying products, Creative Biolabs engages in collaborative research.

Can complement reagents be used in combination with flow cytometry or imaging assays?

Absolutely. Several of our antibodies and aptamers are optimized for flow cytometry, immunofluorescence, and confocal microscopy, enabling high-resolution spatial studies of complement activity.