Complement Genetic Test

With the latest state-of-the-art technology and extensive experience, Creative Biolabs is the reliable choice for complement genetic testing, providing the highest standards in genetic testing with the latest technology, strictest quality control, and unprecedented service and reliability.

Background of Complement Genetic Test

In addition to the serological test, genetic test is also important for determining the risk of disease. Genetic defects in complement proteins reportedly contribute to many diseases, such as the atypical hemolytic uremic syndrome, age-related macular degeneration and so on. These diseases have been shown to be associated with uncontrolled activation of the complement pathway. Genetic mutations play a role in such activation, and more than half of patients have causative mutations in complement genes. The common mutation includes loss-of-function mutations in regulators (complement factor H (CFH), complement factor I (CFI), membrane cofactor protein (MCP) and thrombomodulin (THBD)) and gain-of-function mutations in key complement components (C2, C3, C4) and complement factor B (CFB).

The Complement Genetic Test

Comprehensive testing of genetic variants in the complement system is available and helpful for many conditions. Recently, complement genetic testing methodologies for complement genes have advanced to high throughput methods, such as next-generation sequencing (NGS). Nonetheless, in some cases, Sanger sequencing remains the gold standard for complement gene analysis. Even with the use of NGS, Sanger sequencing is required for several complement genes, including CFH and its related proteins-CFHR1-5 due to the presence of highly homologous regions, which can result in false-positive and false-negative variant calls. In addition, copy number analysis is also essential for complement gene analysis and can be performed by NGS or using specialized algorithms or multiplex ligation-dependent probe amplification techniques.

Our Services

Creative Biolabs is a complement test supplier that develops and offers advanced complement genetic testing. For more than a decade, we have been providing genetic testing services to our customers and have earned a considerable reputation for the highest quality service on the market today. Our powerful sequencing technologies and precise bioinformatics pipelines ensure superior genetic testing and report analysis, and our complement genetic test services can address the significant unmet need for accurate and timely diagnosis, monitoring and targeted therapy of complement-related disease. Creative Biolabs performs a comprehensive range of complement genetic tests (C2, C3, C4, CFI, CFH, MCP, CFB, CFHR1-5) for basic and clinical research, including but not limited to:

1. Thrombotic microangiopathy (TMA)
2. Atypical hemolytic uremic syndrome (aHUS)
3. Age-related macular degeneration (AMD)
4. C3 glomerulopathy (C3G)
5. Dense deposit disease (DDD)
6. Thrombotic thrombocytopenic purpura (TTP)
7. Preeclampsia

Why Choose Us?

1. Low sample requirements
2. Screening hundreds of genes and more than 20 associated conditions
3. Short turnaround times - Less than ten business days
4. World-class analysis reports interpreted by genetic experts

The scientists at Creative Biolabs are very confident to deliver you the very best complement genetic service. Our test service is quick, reliable, confidential and affordable. Please feel free to contact us for more information.

• Complement Function/Activity Test
• Complement Autoantibody Test