Anti-ACER1 Aptamer SELEX Service(Cat#: CTApt-1313)

This is an aptamer development services to screening aptamers binds to the ACER1 with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target ACER1
Alternative Names Alkaline Ceramidase 1; N-Acylsphingosine Amidohydrolase (Alkaline Ceramidase) 3; N-Acylsphingosine Amidohydrolase 3; Acylsphingosine Deacylase 3; Alkaline CDase 1; AlkCDase 1; ASAH3; CTB-180A7.3; EC 3.5.1.23; EC 3.5.1.- ; ALKCDase1; ACER1
Gene ID 125981
UniProt ID Q8TDN7
Target Overview Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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