Anti-ACO1 Aptamer SELEX Service(Cat#: CTApt-951)
This is an aptamer development services to screening aptamers binds to the ACO1 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ACO1 |
| Alternative Names |
Aconitase 1; IRP1; Iron-Responsive Element-Binding Protein 1; Aconitate Hydratase, Cytoplasmic; Cytoplasmic Aconitate Hydratase; Ferritin Repressor Protein; Iron Regulatory Protein 1; Cytosplasmic Aconitase; Aconitase 1, Soluble; Citrate Hydro-Lyase; Soluble Aconitase; EC 4.2.1.3; IREB1; IREBP; Epididymis Secretory Sperm Binding Protein; Epididymis Luminal Protein 60; Cytoplasmic Aconitase; Aconitase; IRE-BP 1; EC 4.2.1; IREBP1; ACONS; HEL60; ACO1 |
| Gene ID |
48 |
| UniProt ID |
P21399 |
| Target Overview |
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
