Anti-AIRE Aptamer SELEX Service(Cat#: CTApt-2380)

This is an aptamer development services to screening aptamers binds to the AIRE with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target AIRE
Alternative Names Autoimmune Regulator; Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein; APECED; APS1; PGA1; Autoimmune Regulator (Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy) ; Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy; APECED Protein; AIRE1; APSI; AIRE
Gene ID 326
UniProt ID O43918
Target Overview This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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