Anti-ALOX5 Aptamer SELEX Service(Cat#: CTApt-2398)
This is an aptamer development services to screening aptamers binds to the ALOX5 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ALOX5 |
| Alternative Names |
Arachidonate 5-Lipoxygenase; Polyunsaturated Fatty Acid 5-Lipoxygenase; EC 1.13.11.34; 5-LOX; 5-LO; LOG5; Arachidonic 5-Lipoxygenase Delta-10-13 Isoform; Arachidonic 5-Lipoxygenase Delta-P10 Isoform; Arachidonic 5-Lipoxygenase Alpha-10 Isoform; Arachidonic 5-Lipoxygenase Delta-13 Isoform; Arachidonic Acid 5-Lipoxygenase; Leukotriene A4 Synthase; 5-Lipoxygenase; EC 1.13.11.- ; EC 1.13.11; LOX-5; ALOX5; 5LPG |
| Gene ID |
240 |
| UniProt ID |
P09917 |
| Target Overview |
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
