Anti-AMACR Aptamer(Cat#: CTApt-1155)

This product is an aptamer which binds to the AMACR with an affinity of <50 nM.

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Summary

Specifications
Target Category Protein
Target AMACR
Alternative Names Alpha-Methylacyl-CoA Racemase; 2-Methylacyl-CoA Racemase; P504S; RACE; EC 5.1.99.4; AMACRD; CBAS4; AMACR; RM
Gene ID 23600
UniProt ID Q9UHK6
Target Overview This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
Chemical Modification DNA
Length 40-60 nt
Affinity (Kd) <50 nM
Binding Conditions/Buffer 50 mM Tris-HCl, 100 mM NaCl, 4 mM KCl, 2.5 mM MgCl₂ and 1 mM CaCl₂, pH 7.4
GC Content 50
Molecular Weight 18332.9
Extinction Coefficient 569400
nmoles/OD260 1.578
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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