Anti-Aminoglycosides Aptamer(Cat#: CTMM-0624-LH14)
This product is a customized aptamer which binds to Aminoglycosides with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Antibiotic |
| Target |
Aminoglycosides |
| Alternative Names |
AMGs |
| Target Overview |
Aminoglycosides (AMGs) are RNA-binding antibiotics sharing a common core structure, the streptamine ring. They function by binding to bacterial ribosomes, causing frameshifting resulting in the production of nonsense peptides, eventually leading to cell death. Their clinical use has been restricted due to toxic side effects, especially to the kidneys and the ear. However, their low cost means that they are still often widely used in animal husbandry leading to potential residues in the food chain. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
N/A |
| GC Content |
56% |
| Molecular Weight |
25372 g/mole |
| nmoles/OD260 |
1.057 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
