Anti-ANAPC5 Aptamer SELEX Service(Cat#: CTApt-1173)

This is an aptamer development services to screening aptamers binds to the ANAPC5 with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target ANAPC5
Alternative Names Anaphase Promoting Complex Subunit 5; APC5; Anaphase-Promoting Complex Subunit 5; Cyclosome Subunit 5; ANAPC5
Gene ID 51433
UniProt ID Q9UJX4
Target Overview This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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