Anti-APC Aptamer SELEX Service(Cat#: CTApt-2107)
This is an aptamer development services to screening aptamers binds to the APC with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
APC |
| Alternative Names |
APC Regulator Of WNT Signaling Pathway; DP2.5; Protein Phosphatase 1, Regulatory Subunit 46; APC, WNT Signaling Pathway Regulator; Adenomatous Polyposis Coli Protein; Deleted In Polyposis 2.5; PPP1R46; DP2; DP3; Adenomatosis Polyposis Coli Tumor Suppressor; Epididymis Secretory Sperm Binding Protein; Truncated Adenomatosis Polyposis Coli; Adenomatous Polyposis Coli (APC) ; WNT Signaling Pathway Regulator; Adenomatosis Polyposis Coli; Adenomatous Polyposis Coli; Protein APC; BTPS; DESM; APC; GS |
| Gene ID |
324 |
| UniProt ID |
P25054 |
| Target Overview |
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
