Anti-APEX2 Aptamer SELEX Service(Cat#: CTApt-1213)
This is an aptamer development services to screening aptamers binds to the APEX2 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
APEX2 |
| Alternative Names |
Apurinic/Apyrimidinic Endodeoxyribonuclease 2; APEXL2; APE2; XTH2; APEX Nuclease (Apurinic/Apyrimidinic Endonuclease) 2; DNA-(Apurinic Or Apyrimidinic Site) Endonuclease 2; Zinc Finger, GRF-Type Containing 2; AP Endonuclease XTH2; AP Endonuclease 2; ZGRF2; DNA-(Apurinic Or Apyrimidinic Site) Lyase 2; Apurinic/Apyrimidinic Endonuclease-Like 2; Apurinic-Apyrimidinic Endonuclease 2; APEX Nuclease-Like 2; APEX Nuclease 2; APEX2 |
| Gene ID |
27301 |
| UniProt ID |
Q9UBZ4 |
| Target Overview |
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
