This is an aptamer development services to screening aptamers binds to the ASAH2 with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | ASAH2 |
| Alternative Names | N-Acylsphingosine Amidohydrolase 2; Non-Lysosomal Ceramidase; Neutral Ceramidase; N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2; Acylsphingosine Deacylase 2; EC 3.5.1.23; N-CDase; BCDase; LCDase; NCDase; HNAC1; Neutral/Alkaline Ceramidase; Mitochondrial Ceramidase; EC 3.5.1.- ; ASAH2; HCD |
| Gene ID | 56624 |
| UniProt ID | Q9NR71 |
| Target Overview | Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]). |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |