Anti-ASAP2 Aptamer SELEX Service(Cat#: CTApt-1224)
This is an aptamer development services to screening aptamers binds to the ASAP2 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ASAP2 |
| Alternative Names |
ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 2; PAP; Arf-GAP With SH3 Domain, ANK Repeat And PH Domain-Containing Protein 2; Paxillin-Associated Protein With ARF GAP Activity 3; Development And Differentiation-Enhancing Factor 2; Pyk2 C-Terminus-Associated Protein; Centaurin, Beta 3; KIAA0400; CENTB3; DDEF2; SHAG1; PAG3; Development And Differentiation Enhancing Factor 2; PYK2 C Terminus-Associated Protein; Pap-Alpha; AMAP2; ASAP2 |
| Gene ID |
8853 |
| UniProt ID |
O43150 |
| Target Overview |
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
