Anti-BAG3 aptamer(Cat#: CTApt-1685)
This product is an aptamer which binds to the BAG3 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
BAG3 |
| Alternative Names |
BAG Cochaperone 3; BAG Family Molecular Chaperone Regulator 3; BCL2 Associated Athanogene 3; Bcl-2-Binding Protein Bis; Docking Protein CAIR-1; BAG-3; BIS; Bcl-2-Binding Protein BIS Transcript ; Bcl-2-Associated Athanogene 3; BCL2-Binding Athanogene 3; CAIR-1; MFM6; BAG3 |
| Gene ID |
9531 |
| UniProt ID |
O95817 |
| Target Overview |
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
