Anti-BAP1 aptamer SELEX Service(Cat#: CTApt-1871)

This is an aptamer development services to screening aptamers binds to the BAP1 with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target BAP1
Alternative Names BRCA1 Associated Protein 1; BRCA1 Associated Protein-1 (Ubiquitin Carboxy-Terminal Hydrolase) ; Ubiquitin Carboxyl-Terminal Hydrolase BAP1; Cerebral Protein 6; KIAA0272; Hucep-6; UCHL2; Ubiquitin Carboxy-Terminal Hydrolase; BRCA1-Associated Protein 1; Cerebral Protein-13; EC 3.4.19.12; HUCEP-13; BAP1
Gene ID 8314
UniProt ID Q92560
Target Overview This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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