Anti-BCAR3 aptamer SELEX Service(Cat#: CTApt-1706)
This is an aptamer development services to screening aptamers binds to the BCAR3 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
BCAR3 |
| Alternative Names |
BCAR3 Adaptor Protein, NSP Family Member; SH2D3B; NSP2; Breast Cancer Anti-Estrogen Resistance Protein 3; Breast Cancer Anti-Estrogen Resistance 3; BCAR3, NSP Family Adaptor Protein; SH2 Domain-Containing Protein 3B; Novel SH2-Containing Protein 2; Migration Inducting Gene-7; AND-34; MIG7; DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3) ; Breast Cancer Antiestrogen Resistance 3 Protein; Epididymis Secretory Sperm Binding Protein; Mig-7; BCAR3 |
| Gene ID |
8412 |
| UniProt ID |
O75815 |
| Target Overview |
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
