Anti-BTRC aptamer SELEX Service(Cat#: CTApt-1853)
This is an aptamer development services to screening aptamers binds to the BTRC with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
BTRC |
| Alternative Names |
Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase; FBXW1A; F-Box And WD Repeats Protein Beta-TrCP; F-Box/WD Repeat-Containing Protein 1A; PIkappaBalpha-E3 Receptor Subunit; Epididymis Tissue Protein Li 2a; E3RSIkappaB; Beta-TrCP1; BetaTrCP; BTrCP1; FBW1A; BTrCP; Beta-Transducin Repeat Containing; F-Box And WD-Repeat Protein 1B; BETA-TRCP; FBXW1; BTRCP; FWD1; BTRC; Fwd1 |
| Gene ID |
8945 |
| UniProt ID |
Q9Y297 |
| Target Overview |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
