Anti-Gastrin Releasing Peptide Aptamer(Cat#: CTApt-117)

This product is an aptamer which binds to the Pro-gastrin releasing peptide (31-98 a.a.) with an affinity of <100 nM.

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Specifications
Target Category Protein
Target Gastrin-Releasing Peptide Receptor (GRPR) aka BB2 Receptor)
Alternative Names Gastrin Releasing Peptide; Gastrin-Releasing Peptide; Neuromedin C; Prepro-GRP; Bombesin; Pre-Progastrin Releasing Peptide; Testicular Tissue Protein Li 103; PreproGRP; GRP-10; ProGRP; BN
Gene ID 2922
UniProt ID P07492
Target Overview This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Chemical Modification Peptide
Type DNA
Length <50 nt
Affinity (Kd) <100 nM
Binding Conditions/Buffer 100 mM NaCl, 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, 20 mM Tris–HCl, 0.02% Tween 20, pH = 7.6
GC Content 50%
Molecular Weight 14789.65 g/mole
Extinction Coefficient 460200
nmoles/OD260 2.17

Customer Review

A valuable tool in our lab experiments
Excellent
Its versatility in different assay formats saved us time and resources. Plus, the technical support from the company was outstanding-prompt and helpful.
Outstanding results
Excellent
It enabled us to conduct our experiments with confidence, and we achieved publication-worthy data. The technical support team was responsive and assisted us with any queries we had.
Overall, the anti-GRP aptamer is excellent
Excellent
The anti-GRP aptamer demonstrated remarkable specificity and sensitivity, which helped us unravel complex signaling pathways. We have already recommended it to our colleagues.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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